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Normal Range for anti-IgG = 0 - 20 GPL; Normal
Range for anti-IgM = 0 - 10 MPL.
It is the antibody to the cell membrane.
Found in approx 33% lupus patients, lupus specificity
is fair.
Antibodies to cardiolipin have been associated with
an incresased incidence of vascular thrombosis, thrombocytopenia
and recurrent fetal loss in patients with SLE. Increased in: SLE,
some connective tissue diseases, and in Antiphospholipid Syndrome
(Hughes Syndrome).
Patients with acute and chronic infections (including
syphilis, HIV, Lyme disease) may also have increased anti-cardiolipin
antibodies.
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