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Normal Range = < 1:10 titer.
Anti-DNA is an immunoglobulin specific against native
(double-stranded) DNA
It is increased in Systemic lupus erythematosus &
is highly specific to SLE.
Sixty to eighty percent of patients with active SLE have a positive
anti-DNA test.
Anti-ds-DNA antibody is not found in drug-induced
lupus.
Titers of anti-ds-DNA correlate well with disease activity and with
occurrence of glomerulonephritis.
A positive test means = In a person with lupus symptoms,
a positive test almost always means that lupus is present. However,
the test can also be positive in some patients with rare diseases.
A negative test means = a negative test does not
mean that lupus is not present.
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