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These immunoglobulins, commonly found together, are specific against
RNA proteins
Normal Range = Negative.
It is positive in Primary Sjogren's syndrome (70%),
SLE (30%), rheumatoid arthritis (10%).
Patients with antibodies to SS-A may have a negative
ANA test.
Anti-Ro is highly associated with photosensitivity;
both are associated with neonatal lupus.
Lupus specificity is fair.
A positive test means -In pregnant women, it can cause
the condition known as neonatal lupus. Approx. one quarter of the
women who have this antibody, will have a child who develops neonatal
lupus.
A negative test means - If both this test and the
anti-La/SSB test are negative, the child of a pregnant woman will
not develop neonatal lupus.
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