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Mixed Connective Tissue Disease resembles lupus, it has features
of lupus, but also of scleroderma.
It is characterised by four main features -
Raynaud's Phenomenon - Fingers suddenly become cold & turn
white, blue, & finally red when circulation returns. The Raynaud's
Phenomenon in MCTD is more prominent than in lupus, and is reminiscent
of scleroderma.
Prominent arthritis - In MCTD, arthritis is more like rheumatoid
arthritis with swelling, especially in the fingers and the fingers
become "sausage-like". Other joints may also be involved.
The absence (or rarity) of many general features of lupus,
such as kidney disease.
A specific blood test - the anti-RNP - must be positive
for a diagnosis of MCTD
There may also be inflammation of the muscles (myositis), with
muscle weakness & pain.
Treatment
MCTD is treated with steroids (low-moderate doses), & some
patients respond well to Methotrexate.
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