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WEDNESDAY, June 30 (HealthDayNews) -- A protein that provides early
warning of kidney disease in people with the autoimmune disorder
lupus has been identified by University of Florida scientists.
Lupus patients with kidney disease have markedly increased levels
of this protein, called MCP1, in their urine. This means a simple
urine test can be developed to let doctors check for the presence
of the protein as an early indicator of kidney disease and take
appropriate treatment measures.
"All we can do now is quote newly diagnosed lupus patients
the statistics for the chance of kidney disease," study co-author
Dr. Hanno B. Richards, co-director of the university's Lupus Clinic,
said in a prepared statement.
"We can offer detailed genetic testing and assess what the
likelihood of the disease might be. But with MCP1, we can screen
for the levels in the urine and base our need for treatment on that,"
Richards said.
He and his colleagues found that kidney disease was about two
to three times more likely to develop in lupus patients with particular
genetic variants that produce MCP1, which directs immune system
cells toward areas of inflammation.
Kidney disease affects about half of the 1.5 million Americans
who have lupus.
The study appears in the current issue of Arthritis and Rheumatism.
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