Lupus Site - a guide for lupus patients and their families

Compared with the general population, lupus patients are perhaps twice as likely to suffer from migraine-like headaches.
Many patients also have antiphospholipid antibodies, while others display Raynaud's phenomenon.

Lupus headache is managed much like conventional migraine, using painkillers, anti-inflammatories, vasoconstrictors, & sometimes beta-blockers, or tricyclic antidepressants.
Lupus headache is different to most migraines, since patients may respond to a 1 week trial of 20-60 milligrams of prednisone daily, which is rarely useful to migraine sufferers.